Sarah's Wager

# Summary In November 2025, Anthropic released Claude Opus 4.5, an AI model that fundamentally transformed AI capabilities by enabling autonomous agents that could complete complex tasks without step-by-step human guidance. The breakthrough made AI systems dramatically more capable and practical—capable programmers like Andrej Karpathy stopped writing code themselves, and tech leaders like Nat Friedman began delegating personal health decisions to AI agents. This represents a major inflection point where AI transitioned from requiring constant human direction to operating independently and proactively.